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10.1016/j.biomaterials.2013.12.029 153 WikesjU
MACE = major adverse cardiovascular events
What Is AOD-9604 AOD-9604 is a 16-residue synthetic peptide, supplied as a lyophilized solid for laboratory research
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In isolated rat aorta preparations, the peptide produced concentration-dependent vasodilation that was endothelium-dependent and abolished by L-NAME, and co-immunoprecipitation work traced the response to phosphorylation of Src, caveolin-1, and endothelial nitric oxide synthase, with reduced binding between caveolin-1 and eNOS [1]
